Fire Rescue Victoria (FRV) fire fighters responded to an incident just after 4:00pm in Truganina following a call to Triple Zero.
Fire crews arrived at Everton Road to find a two storey property in flames. Wearing breathing apparatus, fire fighters entered the home to prevent the fire from spreading, while outside fire fighters protected neighbouring properties.
All occupants of the property were safely evacuated and the fire declared under control at 4:52pm.
Flames burst through the roof of the property and part of the roof collapsed, and smoke was visible in the area.
No cause has been determined yet, but looks accidental. Initial reports were that the fire started in an oven.
Victoria Police and Ambulance Victoria were also on the scene.